Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors.

@article{Shan2008LeptinenhancedNH,
  title={Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors.},
  author={Jian Cheng Shan and Thomas B. V. Nguyen and Hana Totary-Jain and Hayes M. Dansky and Steven O. Marx and Andrew Robert Marks},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 48},
  pages={19006-11}
}
Despite the use of the sirolimus (rapamycin) drug-eluting coronary stent, diabetics are at increased risk of developing in-stent restenosis for unclear reasons. Hyperleptinemia, which often coexists with diabetes and metabolic syndrome, is an independent risk factor for progression of coronary artery disease. It has not been determined whether elevated circulating leptin decreases the efficacy of the sirolimus drug-eluting stent in inhibiting neointimal hyperplasia, the process underlying… CONTINUE READING

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Hyperleptinemia , which often coexists with diabetes and metabolic syndrome , is an independent risk factor for progression of coronary artery disease .
Hyperleptinemia , which often coexists with diabetes and metabolic syndrome , is an independent risk factor for progression of coronary artery disease .
Hyperleptinemia , which often coexists with diabetes and metabolic syndrome , is an independent risk factor for progression of coronary artery disease .
Hyperleptinemia , which often coexists with diabetes and metabolic syndrome , is an independent risk factor for progression of coronary artery disease .
Hyperleptinemia , which often coexists with diabetes and metabolic syndrome , is an independent risk factor for progression of coronary artery disease .
ObesityNo subtypeleptin
Exogenous leptin , administered at levels comparable to those found in obese humans , promotes neointimal VSMC hyperplasia in a murine femoral artery wire injury model .
leptinNo subtypeObesity
Exogenous leptin , administered at levels comparable to those found in obese humans , promotes neointimal VSMC hyperplasia in a murine femoral artery wire injury model .
Hyperleptinemia , which often coexists with diabetes and metabolic syndrome , is an independent risk factor for progression of coronary artery disease .
Hyperleptinemia , which often coexists with diabetes and metabolic syndrome , is an independent risk factor for progression of coronary artery disease .
Hyperleptinemia , which often coexists with diabetes and metabolic syndrome , is an independent risk factor for progression of coronary artery disease .
Hyperleptinemia , which often coexists with diabetes and metabolic syndrome , is an independent risk factor for progression of coronary artery disease .
These studies may explain the higher rates of restenosis observed in diabetics treated with a sirolimus - eluting coronary stent and suggest a potential novel therapeutic approach for inhibiting in - stent restenosis in such patients .
Despite the use of the sirolimus ( rapamycin ) drug - eluting coronary stent , diabetics are at increased risk of developing in - stent restenosis for unclear reasons .
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