Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.

@article{Fujikawa2013LeptinEA,
  title={Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.},
  author={Teppei Fujikawa and Eric D. Berglund and Vishal R. Patel and Giorgio Ramadori and Claudia R. Vianna and Linh H Vong and Fabrizio Thorel and Simona Chera and Pedro L Herrera and Bradford Barr Lowell and Joel K Elmquist and Pierre Baldi and Roberto Coppari},
  journal={Cell metabolism},
  year={2013},
  volume={18 3},
  pages={
          431-44
        }
}
The dogma that life without insulin is incompatible has recently been challenged by results showing the viability of insulin-deficient rodents undergoing leptin monotherapy. Yet, the mechanisms underlying these actions of leptin are unknown. Here, the metabolic outcomes of intracerebroventricular (i.c.v.) administration of leptin in mice devoid of insulin and lacking or re-expressing leptin receptors (LEPRs) only in selected neuronal groups were assessed. Our results demonstrate that… CONTINUE READING
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