Leptin depolarizes rat hypothalamic paraventricular nucleus neurons.

@article{Powis1998LeptinDR,
  title={Leptin depolarizes rat hypothalamic paraventricular nucleus neurons.},
  author={Jeff Earl Powis and Jaideep Singh Bains and Alastair V Ferguson},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1998},
  volume={274 5},
  pages={R1468-R1472}
}
Leptin, the protein product of the ob/ obgene, is thought to have a central site of action, presumably within the hypothalamus, through which it regulates feeding behavior. The paraventricular nucleus (PVN) is one structure that has been implicated in regulating feeding behavior. Using patch-clamp recording techniques, this study examines the direct membrane effects of leptin on neurons in a coronal PVN slice. Bath application of the physiologically active leptin fragment (amino acids 22-56… CONTINUE READING

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