Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes.

@article{Batra2007LeptindependentTR,
  title={Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes.},
  author={Arvind Batra and Jeannette Pietsch and Inka Fedke and Rainer Glauben and Besir Okur and Thorsten Stroh and Martin Zeitz and Britta Siegmund},
  journal={The American journal of pathology},
  year={2007},
  volume={170 6},
  pages={1931-41}
}
Leptin, an adipokine mainly produced by adipocytes, has been well characterized with regard to its regulatory function on immune cells. Thus the question occurred of how adipocytes and preadipocytes interact with the immune system and whether or not this communication is regulated by leptin. With the present study we evaluated the Toll-like receptor (TLR) expression and TLR ligand-specific activation of murine preadipocytes and adipocytes in the presence [wild type (WT), 3T3L1] or absence of… CONTINUE READING