Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction.

  title={Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction.},
  author={Nicole Bellefontaine and Konstantina Chachlaki and Jyoti Parkash and Charlotte Vanacker and William H Colledge and Xavier d'Anglemont de Tassigny and John Garthwaite and S{\'e}bastien Bouret and Vincent Prevot},
  journal={The Journal of clinical investigation},
  volume={124 6},
The transition to puberty and adult fertility both require a minimum level of energy availability. The adipocyte-derived hormone leptin signals the long-term status of peripheral energy stores and serves as a key metabolic messenger to the neuroendocrine reproductive axis. Humans and mice lacking leptin or its receptor fail to complete puberty and are infertile. Restoration of leptin levels in these individuals promotes sexual maturation, which requires the pulsatile, coordinated delivery of… CONTINUE READING
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Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance

  • RL Leshan, M Greenwald-Yarnell, CM Patterson, IE Gonzalez, MG Myers, MG Jr.Myers
  • Nat Med
  • 2012
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