Leptin controls the fate of fatty acids in isolated rat white adipocytes.

@article{William2002LeptinCT,
  title={Leptin controls the fate of fatty acids in isolated rat white adipocytes.},
  author={William N William and Rolando Bacis Ceddia and R. A. Curi},
  journal={The Journal of endocrinology},
  year={2002},
  volume={175 3},
  pages={735-44}
}
Leptin directly increases the rate of exogenous glucose and fatty acids oxidation in isolated adipocytes. However, the effects of leptin on fatty acid metabolism in white adipose tIssue have not been examined in detail. Here, we report that in adipocytes incubated for 6 h in the presence of leptin (10 ng/ml), the insulin-stimulated de novo fatty acid synthesis was inhibited by 36% (P<0.05), while the exogenous oxidation of acetic and oleic acids was increased by 50% and 76% respectively… CONTINUE READING
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