Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice.

@article{Chen1997LeptinCA,
  title={Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice.},
  author={Ningfang Chen and Andrew G. Swick and Dale R. Romsos},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 5},
  pages={1174-9}
}
Hypersecretion of insulin from the pancreas is among the earliest detectable metabolic alterations in some genetically obese animals including the ob/ob mouse and in some obesity-prone humans. Since the primary cause of obesity in the ob/ob mouse is a lack of leptin due to a mutation in the ob gene, we tested the hypothesis that leptin targets a regulatory pathway in pancreatic islets to prevent hypersecretion of insulin. Insulin secretion is regulated by changes in blood glucose, as well as by… CONTINUE READING