Leptin concentrations in the polycystic ovary syndrome.

  title={Leptin concentrations in the polycystic ovary syndrome.},
  author={C S Mantzoros and Andrea Dunaif and Jeffrey S. Flier},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={82 6},
The polycystic ovary syndrome (PCOS) is characterized by menstrual disturbances, chronic anovulation and hyperandrogenism and is associated with insulin resistance and hyperinsulinemia. Leptin, the product of the ob gene, is an adipocyte-secreted molecule that signals the magnitude of energy stores to the brain and has been recently shown to have important effects on the reproductive axis of rodents. To assess the potential contribution of leptin to the pathogenesis of PCOS, we measured leptin… CONTINUE READING