Leptin augments coronary vasoconstriction and smooth muscle proliferation via a Rho-kinase-dependent pathway

@article{Noblet2016LeptinAC,
  title={Leptin augments coronary vasoconstriction and smooth muscle proliferation via a Rho-kinase-dependent pathway},
  author={Jillian N. Noblet and Adam G Goodwill and Daniel Sassoon and Alexander M. Kiel and Johnathan D. Tune},
  journal={Basic Research in Cardiology},
  year={2016},
  volume={111},
  pages={1-14}
}
Leptin has been implicated as a key upstream mediator of pathways associated with coronary vascular dysfunction and disease. The purpose of this investigation was to test the hypothesis that leptin modifies the coronary artery proteome and promotes increases in coronary smooth muscle contraction and proliferation via influences on Rho kinase signaling. Global proteomic assessment of coronary arteries from lean swine cultured with obese concentrations of leptin (30 ng/mL) for 3 days revealed… CONTINUE READING