Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases.

  title={Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases.},
  author={Juanita H. J. Vernooy and Niki D J Ubags and Guy G Brusselle and Jan Tavernier and Benjamin T Suratt and Guy F Joos and Emiel F. M. Wouters and Ken R Bracke},
  journal={Pulmonary pharmacology & therapeutics},
  volume={26 4},
Leptin is an adipocyte-derived hormone, recognized as a critical mediator of the balance between food intake and energy expenditure by signalling through its functional receptor (Ob-Rb) in the hypothalamus. Structurally, leptin belongs to the long-chain helical cytokine family, and is now known to have pleiotropic functions in both innate and adaptive immunity. The presence of the functional leptin receptor in the lung together with evidence of increased airspace leptin levels arising during… CONTINUE READING


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