Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

@inproceedings{Stefanou2009LeptinAA,
  title={Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase},
  author={Nikolaos Stefanou and Vassilis K. Papanikolaou and Yoichi Furukawa and Yusuke Nakamura and Aspasia Tsezou},
  booktitle={BMC Cancer},
  year={2009}
}
BackgroundNumerous epidemiological studies have documented that obesity is associated with hepatocellular carcinoma (HCC). The aim of this study was to investigate the biological actions regulated by leptin, the obesity biomarker molecule, and its receptors in HCC and the correlation between leptin and human telomerase reverse transcriptase (hTERT), a known mediator of cellular immortalization.MethodsWe investigated the relationship between leptin, leptin receptors and hTERT mRNA expression in… CONTINUE READING

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