Leptin and thyrotropin-releasing hormone: cooperative action in the hindbrain to activate brown adipose thermogenesis.

@article{Hermann2006LeptinAT,
  title={Leptin and thyrotropin-releasing hormone: cooperative action in the hindbrain to activate brown adipose thermogenesis.},
  author={Gerlinda E Hermann and Maria J. Barnes and Richard C. Rogers},
  journal={Brain research},
  year={2006},
  volume={1117 1},
  pages={118-24}
}
Explanations of leptin induction of thermogenesis typically involve primary detection elements in the hypothalamus. In turn, these circuits control medullary raphe neurons that regulate spinal efferent sympathetic projections to heat-producing brown adipose tissue (BAT). The hindbrain may be capable of considerable thermoregulatory capacity independent of the hypothalamus, though little is known about the site(s), mechanism(s) of action, or the physiological consequences of leptin action in the… CONTINUE READING

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