Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity.

@article{Oswal2010LeptinAT,
  title={Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity.},
  author={Ashwini Oswal and Giles S. H. Yeo},
  journal={Obesity},
  year={2010},
  volume={18 2},
  pages={
          221-9
        }
}
  • Ashwini Oswal, Giles S. H. Yeo
  • Published 2010
  • Medicine
  • Obesity
  • summaRy Although we have alluded to the fact that a vast number of peripheral and central signals contribute to energy homeosta-sis, in this article we focus specifically on the leptin signal as an exemplary model of body weight control. We review the evidence challenging the classic view that leptin acts primarily at the ARC to control satiety through the melanocor-tin pathway. Instead an updated picture is presented whereby leptin acts through a distributed network of intercommu-nicating… CONTINUE READING

    Figures and Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 145 CITATIONS, ESTIMATED 47% COVERAGE

    Implications of leptin in neuroendocrine regulation of male reproduction.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Leptin in human physiology and pathophysiology.

    New concepts in white adipose tissue physiology

    FILTER CITATIONS BY YEAR

    2010
    2020

    CITATION STATISTICS

    • 4 Highly Influenced Citations

    • Averaged 9 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 112 REFERENCES

    Mechanisms of leptin action and leptin resistance.

    VIEW 1 EXCERPT

    The blood-brain barrier as a cause of obesity.