Leptin and the cardiovascular system: a review.

  title={Leptin and the cardiovascular system: a review.},
  author={Patel J Ashwin and Patel J Dilipbhai},
  journal={Recent patents on cardiovascular drug discovery},
  volume={2 2},
Obesity is an increasing health problem not only in the industrialized western countries but, also in the developing countries like India. The adipose tissue specific obese (ob) gene and its peptide product leptin were discovered in 1994. Leptin binding to specific receptors in the hypothalamus results in altered expression of orexigenic and anorexigenic neuropeptides that regulate neuroendocrine functions and energy homeostasis. Recent patents and experimental evidence suggest that leptin… CONTINUE READING
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