Leptin and the Control of Body Weight: A Review of Its Diverse Central Targets, Signaling Mechanisms, and Role in the Pathogenesis of Obesity

  title={Leptin and the Control of Body Weight: A Review of Its Diverse Central Targets, Signaling Mechanisms, and Role in the Pathogenesis of Obesity},
  author={Ashwini Oswal and Giles S. H. Yeo},
summaRy Although we have alluded to the fact that a vast number of peripheral and central signals contribute to energy homeosta-sis, in this article we focus specifically on the leptin signal as an exemplary model of body weight control. We review the evidence challenging the classic view that leptin acts primarily at the ARC to control satiety through the melanocor-tin pathway. Instead an updated picture is presented whereby leptin acts through a distributed network of intercommu-nicating… 

Implications of leptin in neuroendocrine regulation of male reproduction.

Leptin in human physiology and pathophysiology.

Understanding of the role of leptin and the potential clinical applications of leptin or its analogs in human therapeutics is increased, and another emerging area of research pertains to the discovery and/or usefulness of leptin sensitizers.

Hypothalamic Leptin and Ghrelin Signaling as Targets for Improvement in Metabolic Control.

Obesity has become one of the most important health problems facing the industrialized world, indicating that metabolic equilibrium is frequently disrupted, and understanding how and why this occurs will allow new therapeutical targets to be identified.


Leptin is an adipocytes-secreted hormone of mammals that is derived from the adipose tissue and expressed in the hypothalamus and has important effects in regulating body weight and metabolism.

Leptin in pediatrics: A hormone from adipocyte that wheels several functions in children

The aim of this review is to summarize the possible physiological functions of leptin and its signaling pathways during childhood and adolescence including control of food intake, energy regulation, growth and puberty, and immunity.

New concepts in white adipose tissue physiology

  • A. ProençaR. Sertie F. Lima
  • Biology
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2014
The objective of this review is to provide a comprehensive critical review of the current literature concerning the metabolic (lipolysis, lipogenesis) and endocrine actions of AT.

Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss in humans.

Results from this review demonstrate that even mild weight loss induced by CR may have beneficial effects on leptin levels, but it has no clear impact on adiponectin, resistin, IL-6,IL-8, MCP-1, or RBP-4 concentrations.



Role of leptin in the neuroendocrine response to fasting

It is proposed that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin, and preventing the starvation-induced fall in leptin with exogenous leptin substantially blunts the changes in gonadal, adrenal and thyroid axes in male mice, and prevents the starve-induced delay in ovulation in female mice.

Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function.

Leptin activates autoinhibitory signals via LRb Tyr985 to attenuate the anti-adiposity effects of leptin, especially in females, potentially contributing to leptin insensitivity in obesity.

Mechanisms of leptin action and leptin resistance.

A number of mechanisms, including the leptin-stimulated phosphorylation of Tyr(985) on LRb and the suppressor of cytokine signaling 3, attenuate leptin signaling and promote a cellular leptin resistance in obesity.

The blood-brain barrier as a cause of obesity.

  • W. Banks
  • Biology
    Current pharmaceutical design
  • 2008
It is postulate that hypertriglyceridemia evolved as a starvation signal to the brain that acts in part to inhibit the transport of the leptin across the blood-brain barrier and providing a mechanism for peripheral leptin resistance.

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Leptin is an adipocyte-derived hormone that plays a key role in energy homeostasis, yet resistance to leptin is a feature of most cases of obesity in humans and rodents. In vitro analysis suggested

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

It is reported here that Socs3+/− mice display greater leptin sensitivity than wild-type control mice and are significantly protected against the development of diet-induced obesity and associated metabolic complications.

The role of leptin→STAT3 signaling in neuroendocrine function: an integrative perspective

One LRb signal, STAT3, has recently been shown to play a critical role in the regulation of body weight and some elements of neuroendocrine function (thyroid, adrenal, lactation), although the participation of STAT3 in the gonadal and growth axes is negligible.

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

An integrated model of leptin action and neuronal architecture in the arcuate nucleus of the hypothalamus is proposed and it is shown that melanocortin peptides have an autoinhibitory effect on this circuit.

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

The study suggests that the ARC is selectively leptin resistant in DIO mice and that this may be caused by elevated suppressor of cytokine signaling 3 in this hypothalamic nucleus.