Leptin and renal disease.

  title={Leptin and renal disease.},
  author={Gunter B Wolf and Sheldon Chen and Dong Cheol Han and Fuad N. Ziyadeh},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  volume={39 1},
Leptin is a small peptide hormone that is mainly, but not exclusively, produced in adipose tissue. The circulating leptin concentration therefore directly reflects the amount of body fat. Leptin was identified through positional cloning of the obese (ob) gene, which is mutated in the massively obese ob/ob mouse, and it has a pivotal role in regulating food intake and energy expenditure. It binds to the so-called long receptor (Ob-Rb) in the hypothalamus and regulates food intake through the… CONTINUE READING
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