Leptin and leptin receptor expression in asthma.

  title={Leptin and leptin receptor expression in asthma.},
  author={Andreina Bruno and Elisabetta Pace and Pascal Chanez and Delphine Gras and Isabelle Vachier and Giuseppina Chiappara and Maurizio La Guardia and Stefania Gerbino and Mirella Profita and Mark Gjomarkaj},
  journal={The Journal of allergy and clinical immunology},
  volume={124 2},
  pages={230-7, 237.e1-4}
BACKGROUND The adipokine leptin is a potential new mediator for bronchial epithelial homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling that might affect disease chronicity and severity. TGF-beta is a tissue growth factor the dysregulation of which is associated with airway remodeling. OBJECTIVE We sought to determine whether a bronchial epithelial dysfunction of the leptin/leptin receptor pathway contributes to asthma pathogenesis and severity. METHODS… CONTINUE READING