Leptin and adiponectin receptor expression in oesophageal cancer.

  title={Leptin and adiponectin receptor expression in oesophageal cancer.},
  author={Julia M Howard and Mary Clare Cathcart and Laura Healy and Peter Julian Beddy and Conor Muldoon and Graham P. Pidgeon and John Vincent Reynolds},
  journal={The British journal of surgery},
  volume={101 6},
BACKGROUND Oesophageal adenocarcinoma is an exemplar model of an obesity-associated adenocarcinoma. Altered secretion of adipokines by visceral fat is believed to play a key role in tumorigenesis. This study examined leptin receptor (ObR) and adiponectin receptor (AdipoR1 and AdipoR2) expression in oesophageal cancer, and its relationship with patient obesity status, clinicopathological data and patient survival. METHODS Tissue microarrays were constructed from paraffin-embedded… CONTINUE READING