Leptin and Amylin Act in an Additive Manner to Activate Overlapping Signaling Pathways in Peripheral Tissues

@inproceedings{Moon2011LeptinAA,
  title={Leptin and Amylin Act in an Additive Manner to Activate Overlapping Signaling Pathways in Peripheral Tissues},
  author={H Moon and John P Chamberland and Kalliope Nina Diakopoulos and Christina G. Fiorenza and Florencia Ziemke and Benjamin E. Schneider and Christos Socrates Mantzoros},
  booktitle={Diabetes care},
  year={2011}
}
OBJECTIVE Amylin interacts with leptin to alter metabolism. We evaluated, for the first time, amylin- and/or leptin-activated signaling pathways in human peripheral tissues (hPTs). RESEARCH DESIGN AND METHODS Leptin and amylin signaling studies were performed in vitro in human primary adipocytes (hPAs) and human peripheral blood mononuclear cells (hPBMCs) and ex vivo in human adipose tissue (hAT) from male versus female subjects, obese versus lean subjects, and subjects with subcutaneous… CONTINUE READING
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