Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

@article{Rodrguez2014LeptinAA,
  title={Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice},
  author={Amaia Rodr{\'i}guez and Sara Becerril and Leire M{\'e}ndez-Gim{\'e}nez and Beatriz Perdomo Ram{\'i}rez and Neira S{\'a}inz and Victoria Catal{\'a}n and Javier G{\'o}mez-Ambrosi and Gema Fr{\"u}hbeck},
  journal={International Journal of Obesity},
  year={2014},
  volume={39},
  pages={397-407}
}
Background/objetives:Obese leptin-deficient ob/ob mice exhibit high adiposity and reduced muscle mass with leptin replacement promoting weight loss and inducing muscle accretion through PGC-1α-dependent mechanisms. Our aim was to analyze in vivo and in vitro the effect of leptin on FNDC5, a novel PGC-1α-dependent myokine that is synthesized and cleaved to form irisin that induces white adipose browning.Methods/results:Twelve-week-old male wild-type and ob/ob mice were divided in three groups as… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 44 CITATIONS

Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome

VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The role of exercise-induced myokines in regulating metabolism

VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Roles of myokines in exercise-induced improvement of neuropsychiatric function

References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Are skeletal muscle & adipose tissue Fndc5 gene expression and irisin release affected by obesity, diabetes and exercise? In vivo & in vitro studies

  • T Kurdiova, M Balaz, +3 authors L Valkovic
  • J Physiol
  • 2014