Leptin actions on food intake and body temperature are mediated by IL-1.

@article{Luheshi1999LeptinAO,
  title={Leptin actions on food intake and body temperature are mediated by IL-1.},
  author={Giamal N. Luheshi and Jerry Gardner and David A Rushforth and Andrew S. I. Loudon and Nancy J. Rothwell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 12},
  pages={7047-52}
}
Leptin regulates energy balance through its actions in the brain on appetite and energy expenditure and also shares properties with cytokines such as IL-1. We report here that leptin, injected into rats intracerebroventricularly or peripherally, induces significant dose-dependent increases in core body temperature as well as suppression of appetite. Leptin failed to affect food intake or body temperature in obese (fa/fa) Zucker rats, which posses a defective leptin receptor. Furthermore… CONTINUE READING
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Leptin failed to affect food intake or body temperature in obese ( fa / fa ) Zucker rats , which posses a defective leptin receptor .
Leptin failed to affect food intake or body temperature in obese ( fa / fa ) Zucker rats , which posses a defective leptin receptor .
ObesityAssociated with malfunction of gene productleptin receptor
Leptin failed to affect food intake or body temperature in obese ( fa / fa ) Zucker rats , which posses a defective leptin receptor .
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