Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits

@article{Davis2011LeptinRE,
  title={Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits},
  author={Jon F. Davis and Derrick L. Choi and Jennifer D Schurdak and Maureen F. Fitzgerald and Stephen C. Benoit},
  journal={Biological Psychiatry},
  year={2011},
  volume={69},
  pages={668-674}
}
BACKGROUND Overconsumption of calorically dense foods contributes substantially to the current obesity epidemic. The adiposity hormone leptin has been identified as a potential modulator of reward-induced feeding. The current study asked whether leptin signaling within the lateral hypothalamus (LH) and midbrain is involved in effort-based responding for food rewards and/or the modulation of mesolimbic dopamine. METHODS The contribution of endogenous leptin signaling for food motivation and… CONTINUE READING

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Insulin, leptin and reward