Leptin Inhibits Bone Formation through a Hypothalamic Relay A Central Control of Bone Mass

@article{Ducy2000LeptinIB,
  title={Leptin Inhibits Bone Formation through a Hypothalamic Relay A Central Control of Bone Mass},
  author={Patricia Ducy and Michael Amling and Shu Takeda and Matthias H. Priemel and Arndt Friedrich Schilling and Frank Timo Beil and Jianhe Shen and Charles R. Vinson and Johannes Maria Rueger and G{\'e}rard Karsenty},
  journal={Cell},
  year={2000},
  volume={100},
  pages={197-207}
}

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The lack of any changes in plasma total calcium, leptinemia, or hypothalamo-pituitary-corticotropic, -thyrotropic, -somatotropic, or -gonadotropic output suggests that Y2 receptors do not modulate bone formation by humoral mechanisms, and that alteration of autonomic function through hypothalamic Y1 receptors may play a key role in a major central regulatory circuit of bone formation.
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