Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.

Abstract

Obesity is a major risk factor for cardiovascular disease in males and females. Whether obesity triggers cardiovascular disease via similar mechanisms in both the sexes is, however, unknown. In males, the adipokine leptin highly contributes to obesity-related cardiovascular disease by increasing sympathetic activity. Females secrete 3× to 4× more leptin… (More)
DOI: 10.1161/HYPERTENSIONAHA.115.06642

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@article{Huby2016LeptinIH, title={Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.}, author={A Huby and Laszlo Otvos and Eric J. Belin de Chantem{\`e}le}, journal={Hypertension}, year={2016}, volume={67 5}, pages={1020-8} }