Leptin Gene Epigenetic Adaptation to Impaired Glucose Metabolism During Pregnancy

@inproceedings{Bouchard2010LeptinGE,
  title={Leptin Gene Epigenetic Adaptation to Impaired Glucose Metabolism During Pregnancy},
  author={Luigi Bouchard and St{\'e}phanie Thibault and Simon-Pierre Guay and Marta Santur{\'e} and Alexandre Monpetit and Julie St-Pierre and Patrice Perron and Diane Prud'homme Brisson},
  booktitle={Diabetes care},
  year={2010}
}
OBJECTIVE To verify whether the leptin gene epigenetic (DNA methylation) profile is altered in the offspring of mothers with gestational impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS Placental tissues and maternal and cord blood samples were obtained from 48 women at term including 23 subjects with gestational IGT. Leptin DNA methylation, gene expression levels, and circulating concentration were measured using the Sequenom EpiTYPER system, quantitative real-time RT-PCR, and… CONTINUE READING

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