Leptin Effects on Pancreatic β-Cell Gene Expression and Function

@article{Seufert2004LeptinEO,
  title={Leptin Effects on Pancreatic $\beta$-Cell Gene Expression and Function},
  author={Julia Seufert},
  journal={Diabetes},
  year={2004},
  volume={53},
  pages={152-158}
}
  • J. Seufert
  • Published 1 February 2004
  • Biology
  • Diabetes
The hormone leptin is secreted from white adipocytes, and serum levels of leptin correlate with adipose tissue mass. Leptin was first described to act on the satiety center in the hypothalamus through specific receptors (leptin receptor [ObR]) to restrict food intake and enhance energy expenditure. Important peripheral actions of leptin involve inhibition of insulin biosynthesis and secretion in pancreatic β-cells. In turn, insulin stimulates leptin secretion from adipose tissue, establishing a… Expand

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