Leptin--much more than a satiety signal.

  title={Leptin--much more than a satiety signal.},
  author={Ruth B. S. Harris},
  journal={Annual review of nutrition},
Much attention has focused on the effects of leptin as a central satiety agent. There is now a significant amount of evidence that leptin is active in the periphery. This review focuses on the ability of leptin to modify insulin sensitivity, tissue metabolism, stress responses, and reproductive function. Leptin's effect on several of these systems is mediated via the hypothalamic-pituitary axis. Therefore, although in vitro studies provide evidence for direct effects on specific tissues and… CONTINUE READING