Leptin’s Pro-Angiogenic Signature in Breast Cancer

  title={Leptin’s Pro-Angiogenic Signature in Breast Cancer},
  author={Ruben Rene Gonzalez-Perez and Viola Lanier and Gale Newman},
Obesity is linked to increased incidence of breast cancer. The precise causes and mechanisms of these morbid relationships are unknown. Contradictory data on leptin angiogenic actions have been published. However, accumulating evidence would suggest that leptin's pro-angiogenic effects in cancer play an essential role in the disease. Leptin, the main adipokine secreted by adipose tissue, is also abnormally expressed together with its receptor (OB-R) by breast cancer cells. Leptin induces… CONTINUE READING


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Potential role of leptin signaling in DMBA-induced mammary tumors by non-responsive C57BL/6J mice fed a high-fat diet

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