Leptin–leptin receptor are involved in angiogenesis in human hepatocellular carcinoma

  title={Leptin–leptin receptor are involved in angiogenesis in human hepatocellular carcinoma},
  author={Domenico Ribatti and Anna Sandra Belloni and B Nico and Mariasevera Di Comite and Enrico Crivellato and Angelo Vacca},
Recent evidence in vitro and in vivo indicates that leptin, an adipose tissue-secreted hormone which is involved in the regulation of satiety, metabolic rate and thermogenesis, is implicated in angiogenesis. However, the role of leptin-mediated angiogenesis in hepatic carcinogenesis has not yet been completely elucidated. In this study, we have correlated microvascular density and leptin/leptin receptor (Ob-R) expression in endothelial and tumor cells with the histopathological type in human… CONTINUE READING

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