Leptin: cutting the fat off the bone

@article{Cock2003LeptinCT,
  title={Leptin: cutting the fat off the bone},
  author={Terrie-Anne Cock and Johan Auwerx},
  journal={The Lancet},
  year={2003},
  volume={362},
  pages={1572-1574}
}
CONTEXT Leptin was initially proposed to be the antiobesity hormone. Now it is realised that leptin is more a signal molecule that communicates nutritional status to the brain, and that it is involved in bone formation by having an antiosteogenic action. STARTING POINT Recently, Florent Elefteriou and colleagues (Endocrinology 2003; 144: 3842-47) found that hypothalamic neurons control bone mass. These researchers used monosodium glutamate to obliterate neurons in the arcuate nucleus… CONTINUE READING

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