Leptin: a potent inhibitor of insulin secretion.

  title={Leptin: a potent inhibitor of insulin secretion.},
  author={H. C. Fehmann and C Peiser and Heike Bode and Manfred Stamm and Petra Staats and Christoffer Hedetoft and Rudolf E. Lang and Burkhard J. G{\"o}ke},
  volume={18 8},
The hormone leptin is expressed and secreted by the adipose tissue and impacts on the central nervous system. Leptin is involved in the regulation of energy balance, satiety, and body composition. The lack of active leptin results in obesity, high food intake, hyperglycemia, and hyperinsulinemia. We present data supporting effects of leptin on the endocrine pancreas. We found the leptin receptor to be expressed in insulin- and glucagon-secretin cells derived from mouse, hamster, and rat… CONTINUE READING
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