Leptin: a pivotal mediator of intestinal inflammation in mice.

  title={Leptin: a pivotal mediator of intestinal inflammation in mice.},
  author={Britta Siegmund and Hans Anton Lehr and Giamila Fantuzzi},
  volume={122 7},
BACKGROUND & AIMS In addition to acting as a regulator of food intake and energy expenditure, leptin can also modulate immune and inflammatory responses. The role of leptin in intestinal inflammation is the focus of the present study. METHODS Acute and chronic colitis were induced in leptin-deficient ob/ob or wild-type (WT) mice using dextran sulfate sodium (DSS) or trinitrobenzene sulfonic acid (TNBS). The severity of colitis was evaluated, and possible mechanisms were studied. RESULTS… CONTINUE READING