Leptin: a novel link between obesity, diabetes, cardiovascular risk, and ventricular hypertrophy.

@article{Sader2003LeptinAN,
  title={Leptin: a novel link between obesity, diabetes, cardiovascular risk, and ventricular hypertrophy.},
  author={S Lopes Sader and Min Da Nian and Peter Liu},
  journal={Circulation},
  year={2003},
  volume={108 6},
  pages={644-6}
}
Obesity and associated type 2 diabetes mellitus are the emerging epidemic of this new century. Identifying the key mechanism of the pathophysiology offers unique insights into potential prevention and therapy. One of the classic animal models of obesity and insulin resistance has been the ob/ob mouse. Zhang et al1 set the scientific world a-buzz in 1994 with the discovery that the obesity (ob) gene product was in fact leptin, and leptin deficiency accounted for the obesity in these mice. 

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