Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo.

@article{Batra2010LeptinAC,
  title={Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo.},
  author={Arvind Batra and Besir Okur and Rainer Glauben and Ulrike Erben and Jakob Ihbe and Thorsten Stroh and Inka Fedke and Hyun-Dong Chang and Martin Zeitz and Britta Siegmund},
  journal={Endocrinology},
  year={2010},
  volume={151 1},
  pages={56-62}
}
Besides being mandatory in the metabolic system, adipokines like leptin directly affect immunity. Leptin was found to be necessary in T helper 1 (Th1)-dependent inflammatory processes, whereas effects on Th2 cells are rarely understood. Here, we focused on leptin in T-helper cell polarization and in Th2-mediated intestinal inflammation in vivo. The induction of cytokine-producing Th1 or Th2 cells from naive CD4(+) T cells under polarizing conditions in vitro was generally decreased in cells… CONTINUE READING
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