Lepromatous leprosy treated with recombinant interferon gamma: cutaneous histologic changes.

@article{Bottasso1992LepromatousLT,
  title={Lepromatous leprosy treated with recombinant interferon gamma: cutaneous histologic changes.},
  author={Oscar Adelmo Bottasso and Santiago C. Besuschio and Vincent Merlin and Julio C. Morini and Jorge G Bernab{\'o} and R Falcoff and E T Falcoff},
  journal={International journal of dermatology},
  year={1992},
  volume={31 11},
  pages={813-7}
}
We report on the histologic changes occurring in single cutaneous lesions, from six active lepromatous patients, 1 week following the administration of three daily intradermal injections, 35 micrograms each, of recombinant interferon gamma (rIFN-gamma). Except for a strong induration at the injection site, rIFN-gamma produced no adverse systemic reactions and was able to promote a remarkable influx of T-lymphocytes, mononuclear phagocytes with large nuclei, nonvacuolated cytoplasm, and reduced… CONTINUE READING
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