Leonurine Attenuates Hyperalgesia in Mice with Induced Adenomyosis

  title={Leonurine Attenuates Hyperalgesia in Mice with Induced Adenomyosis},
  author={J. Nie and Xi-shi Liu},
  journal={Medical Science Monitor : International Medical Journal of Experimental and Clinical Research},
  pages={1701 - 1706}
  • J. Nie, Xi-shi Liu
  • Published 2017
  • Medicine
  • Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Adenomyosis, defined as the invasion of endometrial glands and stroma into the myometrium, is a common gynecological disorder. In the present study we report on the effect of leonurine on ICR mice with adenomyosis induced by neonatal tamoxifen. Material/Method After being treated with tamoxifen for 4, 8, and 12 weeks, we assessed body weight and pain modulation in mice in hotplate tests. The mice were divided into 5 groups: a low-dose leonurine treatment group, a high-dose leonurine… Expand
Adenomyosis: Mechanisms and Pathogenesis.
Elucidating mechanisms underlying the pathogenesis of adenomyosis raise possibilities to develop targeted therapies to ameliorate symptoms beyond the current agents that are largely ineffective. Expand
Animal Models of Adenomyosis.
Animal models represent a unique opportunity for understanding the molecular basis of adenomyosis and developing efficacious treatment options for affected women and are assessed for different potentials and limitations with regard to identification of new therapeutic interventions. Expand
Rhein ameliorates adenomyosis by inhibiting NF-κB and β-Catenin signaling pathway.
  • T. Feng, ShaoBin Wei, +4 authors X. Fan
  • Medicine, Biology
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2017
The ability of rhein to inhibit Wnt/β- catenin activation and its potential use in the treatment of adenomyosis and other abnormal activation of β-catenin -associated diseases is demonstrated. Expand
Leonurine: From Gynecologic Medicine to Pleiotropic Agent
The pharmacological actions and biological functions of leonurine are reviewed, with a focus on the role of le onurine in the amelioration of various pathological processes. Expand
Leonurine Exerts Anti-Catabolic and Anti-Apoptotic Effects via Nuclear Factor kappa B (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways in Chondrocytes
  • Pengfei Hu, Fang-Fang Sun, J. Qian
  • Chemistry, Medicine
  • Medical science monitor : international medical journal of experimental and clinical research
  • 2019
Results of this study indicate that leonurine exerts anti-catabolic and anti-apoptotic effects in chondrocytes in vitro via suppression of the NF-κB and MAPK signaling pathways. Expand
Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview.
Owing to its excellent therapeutic effects for obstetrical and gynecological diseases, L. japonicus has been widely used in both ancient and modern times and has also been developed into a series of Chinese patent medicines in clinics in China. Expand
Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2‐related factor 2 pathway
It is determined that leonurine prevents ischemic injury of brain tissues via Nrf‐2 pathway activation. Expand


Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis
VPA seems to be a promising therapeutics for treating adenomyosis, as reported recently in some case series in humans. Expand
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  • Medicine
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Oestrogen metabolism, including the expression pattern of aromatase and the regulation of 17beta-hydroxysteroid dehydrogenase type 2 is altered in the eutopic endometrium of women with endometriosis, adenomyosis, and/or leiomyomas compared to that in the gynaecological disorder of women without disease. Expand
Neonatal tamoxifen treatment of mice leads to adenomyosis but not uterine cancer.
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  • Biology, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
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The neonatal mouse, exquisitely sensitive to xenobiotic estrogens, has been used to investigate the effects of short-term oral dosing with tamoxifen on long-term changes in uterine pathology and gene expression and results provide a basis for understanding the mechanism for tamoxIFen induced tissue remodelling and the development of adenomyosis. Expand
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The prerequisite for adenomyosis may be triggered or facilitated by either a 'weakness' of the smooth muscle tissue or an increased intrauterine pressure or both, and relatively high oestrogen concentrations and impaired immune-related growth control in ectopic endometrium may be necessary for the maintenance of adenomeosis. Expand
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Data provide further evidence that dysregulation of the PR-A and PR-B expression might contribute to the pathophysiology of endometriosis. Expand
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Endometriosis is estrogen-dependent, manifests during reproductive years and is associated with pain and infertility, while lesion eradication is considered a fertility-enhancing procedure, the benefit on reproductive performance is moderate. Expand
Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrhea in adenomyosis.
Findings suggest that OTR and TRPV1 may be involved in dysmenorrhea and its severity in adenomyosis and may be potential therapeutic targets. Expand
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  • Medicine
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Various therapeutic options for adenomyosis, including few minimally invasive procedures became available in the last two decades but need evaluation and improvement. Expand
High frequency of adenomyosis in postmenopausal breast cancer patients treated with tamoxifen.
Adenomyosis was significantly more common among postmenopausal breast cancer patients who were treated with TAM as compared to similar patients without TAM treatment, and may be attributed to the continuous and unopposed exposure to TAM. Expand
Recent advances in the understanding of endometriosis: the role of inflammatory mediators in disease pathogenesis and treatment
This review focuses on recent advancements in understanding of the roles of inflammatory mediators in endometriosis pathophysiology and the potential for improved therapies based upon targeting these pathways and the necessity to expand experimental endpoints to include clinically relevant measures when assessing the efficacy of potential new therapies for endometRIosis. Expand