Leonurine Attenuates Hyperalgesia in Mice with Induced Adenomyosis

@article{Nie2017LeonurineAH,
  title={Leonurine Attenuates Hyperalgesia in Mice with Induced Adenomyosis},
  author={J. Nie and Xi-shi Liu},
  journal={Medical Science Monitor : International Medical Journal of Experimental and Clinical Research},
  year={2017},
  volume={23},
  pages={1701 - 1706}
}
  • J. Nie, Xi-shi Liu
  • Published 2017
  • Medicine
  • Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Adenomyosis, defined as the invasion of endometrial glands and stroma into the myometrium, is a common gynecological disorder. In the present study we report on the effect of leonurine on ICR mice with adenomyosis induced by neonatal tamoxifen. Material/Method After being treated with tamoxifen for 4, 8, and 12 weeks, we assessed body weight and pain modulation in mice in hotplate tests. The mice were divided into 5 groups: a low-dose leonurine treatment group, a high-dose leonurine… Expand
Adenomyosis: Mechanisms and Pathogenesis.
TLDR
Elucidating mechanisms underlying the pathogenesis of adenomyosis raise possibilities to develop targeted therapies to ameliorate symptoms beyond the current agents that are largely ineffective. Expand
Animal Models of Adenomyosis.
TLDR
Animal models represent a unique opportunity for understanding the molecular basis of adenomyosis and developing efficacious treatment options for affected women and are assessed for different potentials and limitations with regard to identification of new therapeutic interventions. Expand
Rhein ameliorates adenomyosis by inhibiting NF-κB and β-Catenin signaling pathway.
  • T. Feng, ShaoBin Wei, +4 authors X. Fan
  • Medicine, Biology
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2017
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The ability of rhein to inhibit Wnt/β- catenin activation and its potential use in the treatment of adenomyosis and other abnormal activation of β-catenin -associated diseases is demonstrated. Expand
Leonurine: From Gynecologic Medicine to Pleiotropic Agent
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The pharmacological actions and biological functions of leonurine are reviewed, with a focus on the role of le onurine in the amelioration of various pathological processes. Expand
Leonurine Exerts Anti-Catabolic and Anti-Apoptotic Effects via Nuclear Factor kappa B (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways in Chondrocytes
  • Pengfei Hu, Fang-Fang Sun, J. Qian
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  • Medical science monitor : international medical journal of experimental and clinical research
  • 2019
TLDR
Results of this study indicate that leonurine exerts anti-catabolic and anti-apoptotic effects in chondrocytes in vitro via suppression of the NF-κB and MAPK signaling pathways. Expand
Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview.
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Owing to its excellent therapeutic effects for obstetrical and gynecological diseases, L. japonicus has been widely used in both ancient and modern times and has also been developed into a series of Chinese patent medicines in clinics in China. Expand
Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2‐related factor 2 pathway
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It is determined that leonurine prevents ischemic injury of brain tissues via Nrf‐2 pathway activation. Expand

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