Leontopodic acid—a novel highly substituted glucaric acid derivative from Edelweiss (Leontopodium alpinum Cass.) and its antioxidative and DNA protecting properties

@article{Schwaiger2005LeontopodicAN,
  title={Leontopodic acid—a novel highly substituted glucaric acid derivative from Edelweiss (Leontopodium alpinum Cass.) and its antioxidative and DNA protecting properties},
  author={S. Schwaiger and R. Cervellati and C. Seger and E. Ellmerer and N. About and Isabelle Renimel and Celine Godenir and P. Andr{\'e} and F. Gafner and H. Stuppner},
  journal={Tetrahedron},
  year={2005},
  volume={61},
  pages={4621-4630}
}
Abstract Leontopodic acid—a novel full substituted hexaric acid derivative, was isolated from the aerial parts of Edelweiss ( Leontopodium alpinum Cass.) as one of the major compounds. The complex structure of leontopodic acid-2-[(3 S )-3-hydroxybutanoate]-3,4,5-tris-[(2 E )-3-(3,4-dihydroxyphenyl)-2-propenoate]- d -glucaric acid—was elucidated by mass spectrometry, 1D- and 2D NMR spectroscopy and HPLC monitored transesterification. Leontopodic acid exhibited pronounced antioxidative effects in… Expand
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