Leonard Hayflick and the limits of ageing

  title={Leonard Hayflick and the limits of ageing},
  author={Geoff Watts},
  journal={The Lancet},
  • G. Watts
  • Published 18 June 2011
  • Medicine
  • The Lancet
Molecular and Endocrine Mechanisms Underlying the Stem Cell Theory of Aging
It is suggested that not only are stem cells the mediators of aging but are also the best cellular system to study the causes and consequences of aging in mammals.
Longevity and causes of mortality in elite athletes
French elite athletes show consistently lower mortality in comparison with their compatriots, whether female or male Olympians, or professional cyclists, mostly related with a lower cardiovascular mortality and cancer mortality and this gain shows that cardiovascular longevity benefit is associated with the type of sports practiced during the Olympic career.
Reverse Aging by Punica granatum L
While connecting the dots to all the possibly known diseases, it lead us to a single root cause, an increased level of free-radicals. Apart from the external sources, internally sources as well,
The Role of Cellular Senescence in the Gastrointestinal Mucosa
The Senescence cascade and the cell-cycle checkpoints that dictate the progression and maintenance of senescence are important in all types of gastrointestinal cancers, including pancreatic, liver, gastric, colon, and esophageal cancers.
Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing
The mechanisms of survivals by telomere elongation, DNA damage response and environmental factors in the absence of telomerase maintenance of telomeres in the yeast and mammals are focused on.
Fibroblasts and mesenchymal stem cells: Two sides of the same coin?
It is found that the two cells seem almost identical with respect to their surface immunophenotype, proliferation, and differentiation capacities and even, to an extent, their gene expression profiles and immunomodulatory capacities.
Cellular senescence and senescence‐associated T cells as a potential therapeutic target
  • H. Nakagami
  • Biology, Medicine
    Geriatrics & gerontology international
  • 2019
The depletion of senescent cells in the body, called senolysis, successfully increases lifespan and attenuates age‐related diseases, and this novel therapy is now moving forward to translational research from the bench toward clinical trials.
Comparison of similar cells: Mesenchymal stromal cells and fibroblasts