Leo Kanner and autism: a 75-year perspective
@article{Harris2018LeoKA, title={Leo Kanner and autism: a 75-year perspective}, author={James Harris}, journal={International Review of Psychiatry}, year={2018}, volume={30}, pages={17 - 3} }
Abstract In 1943, Leo Kanner published the first systematic description of early infantile autism. He concluded that this was a neurodevelopmental disorder and that ‘these children have come into the world with an innate inability to form the usual, biologically provided contact with people’. Moreover, his astute descriptions of parental behavior in his first publications were prescient and underlie later recognition of the importance of genetics. Our understanding has grown over the ensuing…
33 Citations
Genetic contributions to autism spectrum disorder
- BiologyPsychological Medicine
- 2021
This review summarizes recent developments in human genetics research in autism, complemented by epigenetic and transcriptomic findings, and considersable increases in sample sizes needed to better understand the hundreds or thousands of common and rare genetic variants involved.
INSIGHT OF AUTISM SCREENING, INTERVENTION AND ITS CORRELATION
- Psychology, MedicineEDULEARN19 Proceedings
- 2019
There should be more research conducted on autism screening itself and the benefits of having an intervention especially in terms of the social and behavior outcome and family relationship.
S0033291721000192jrv 1..14
- Psychology
- 2021
Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental conditions characterized by early childhood-onset impairments in communication and social interaction alongside…
Zebrafish Modeling of Autism Spectrum Disorders, Current Status and Future Prospective
- Psychology, BiologyFrontiers in Psychiatry
- 2022
The presence of orthologous genes for ASD modeling, the anatomical similarities of parts of the brain, and similar neurotransmitter systems between zebrafish and humans are some of the main reasons why scientists draw attention to zebra fish as a prominent animal model in preclinical studies to discover highly effective treatment approaches for the ASD through genetic and non-genetic modeling methods.
Research Progress on the Role of Vitamin D in Autism Spectrum Disorder
- Psychology, BiologyFrontiers in Behavioral Neuroscience
- 2022
This review summarizes the correlation between vitamin D level and ASD, the effects of vitamin D supplementation on autism spectrum disorder, the possible mechanism ofitamin D involved in ASD, and insights from ASD animal models.
Genetic Advances in Autism
- PsychologyJournal of Autism and Developmental Disorders
- 2020
Some of the key findings that are shaping current understanding of autism and what these discoveries mean for clinicians are considered.
Diversity of Intelligence is the Norm Within the Autism Spectrum: Full Scale Intelligence Scores Among Children with ASD.
- PsychologyChild psychiatry and human development
- 2022
Although previous research helped to define differences in intelligence between neurotypicals and those with ASD, results were limited by small sample sizes or restricted subtests. Using data from…
The juniper bush of autism spectrum disorder (ASD): metabolomics, microbiomics, acetaminophen. What else?
- Biology
- 2018
In children with ASD, gut dysbiosis is characterized by the increase in Clostridium, Alistipes, Akkermansia, Caloramator, Sarcina spp .
Autism Spectrum Disorder: A Review of contemporary literature on Common Communication Difficulties and Recommended Research Based Intervention Strategies
- Psychology
- 2021
The aim of this paper is to conduct a general review of contemporary literature about communication difficulties affecting learners with Autism Spectrum Disorder. It further reviews the recommended…
Mapping Research Evidence on Children Living With Autism Spectrum Disorders in Africa: a Scoping Review Protocol.
- Medicine, PsychologyJournal of Pediatrics, Perinatology and Child Health
- 2022
A systematic scoping review that will map all evidence available on children living with Autism Spectrum Disorders in Africa will reveal gaps that can be addressed to ensure context-sensitive interventions and identify caregiver burdens of childrenliving with Autism.
References
SHOWING 1-10 OF 123 REFERENCES
Advances in understanding behavioral phenotypes in neurogenetic syndromes
- PsychologyAmerican journal of medical genetics. Part C, Seminars in medical genetics
- 2010
It is critical to focus on specific behaviors and cognitive patterns in research and not confuse psychiatric symptoms that lack precise definitions and involve multiple genes, the so‐called psychiatric phenotype, with the more specific behavioral phenotype.
Neuropsychological profile of autism and the broad autism phenotype.
- Psychology, BiologyArchives of general psychiatry
- 2009
Data suggest that the social cognitive domain may be an important target for linking phenotype to cognitive process to brain structure in autism and may ultimately provide insight into the genes involved in autism.
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities.
- Biology, PsychologyCold Spring Harbor perspectives in biology
- 2012
Top-down approaches using human phenotypes and genetics and bottom-up approaches applying molecular, biochemical, and neurophysiological studies to genetic models of these disorders revealed unsuspected pathogenic mechanisms and identified potential therapeutic targets.
Brain and behavior in fragile x syndrome and idiopathic autism.
- Psychology, MedicineArchives of general psychiatry
- 2011
using voxel-based neuroimaging analyses, shows significant and distinct differences between the brains of preschool children with fragile X syndrome and idiopathic autism as compared with controls, and finds that brain regions implicated in social cognition were aberrant in preschool boys diagnosed with both syndromes.
Lessons learned from studying syndromic autism spectrum disorders
- Psychology, BiologyNature Neuroscience
- 2016
As new research reveals points of convergence between syndromic and nonsyndromic autism spectrum disorders, it is believed there will be opportunities for shared therapeutics for this class of conditions.
Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting
- Biology, PsychologyBrain Research
- 2011
The Genetics of Autism Spectrum Disorders
- Psychology, Medicine
- 2011
Three approaches to identifying genetic factors that contribute to the pathogenesis of ASDs are reviewed: common variants and genome-wide association studies (GWAS); 2) rare variants and copy number variation (CNV) studies, and 3) familial forms of autism and the role of next-generation sequencing (NGS) methods.
Autism spectrum disorders in genetic syndromes: implications for diagnosis, intervention and understanding the wider autism spectrum disorder population.
- Medicine, PsychologyJournal of intellectual disability research : JIDR
- 2009
There is a need for caution in interpreting the significance of superficial similarities between ASD and the behavioural phenotypes of certain genetically determined syndromes, but recognition of ASD-like characteristics is crucial in ensuring that individuals receive appropriate behavioural management and educational placement.
Broader autism phenotype: evidence from a family history study of multiple-incidence autism families.
- Psychology, MedicineThe American journal of psychiatry
- 1997
Higher rates of social and communication deficits and stereotyped behaviors were found in the relatives in the families with multiple-incidence autism, suggesting that this broader autism phenotype should be included in some future genetic analyses of this disorder.