Lentivirus restriction by diverse primate APOBEC3A proteins.

@article{Schmitt2013LentivirusRB,
  title={Lentivirus restriction by diverse primate APOBEC3A proteins.},
  author={Kimberly Schmitt and K. Guo and M. Katuwal and D. Wilson and Courtney Prochnow and R. Bransteitter and Xiaojiang S. Chen and M. Santiago and E. Stephens},
  journal={Virology},
  year={2013},
  volume={442 1},
  pages={
          82-96
        }
}
Rhesus macaque APOBEC3A (rhA3A) is capable of restricting both simian-human immunodeficiency virus (SHIVΔvif) and human immunodeficiency virus (HIV-1Δvif) to a greater extent than hA3A. We constructed chimeric A3A proteins to define the domains required for differential lentivirus restriction. Substitution of amino acids 25-33 from rhA3A into hA3A was sufficient to restrict HIVΔvif to levels similar to rhA3A restriction of SHIVΔvif. We tested if differential lentivirus restriction is conserved… Expand
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TLDR
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