Lentivirus-mediated silencing of HSDL2 suppresses cell proliferation in human gliomas

  title={Lentivirus-mediated silencing of HSDL2 suppresses cell proliferation in human gliomas},
  author={Chen Ruokun and Xue Yake and Yang Fengdong and Wei Xinting and Song Laijun and Liu Xianzhi},
  journal={Tumor Biology},
Gliomas are the most common type of malignant brain tumors, and the related prognosis is poor. Though many genes have been identified as factors in the development and progression of gliomas, underlying mechanisms remained unclear. It was clear that abnormal lipid metabolism was one of the major hallmarks of cancers. However, few factors associated with lipid metabolism have been reported to be involved in cancer pathogenesis. Hydroxysteroid dehydrogenase-like 2 (HSDL2) is a protein containing… CONTINUE READING


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Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity.

Proceedings of the National Academy of Sciences of the United States of America • 2013
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