Lentivirus-mediated inhibition of AQP4 accelerates motor function recovery associated with NGF in spinal cord contusion rats.

@article{Chen2017LentivirusmediatedIO,
  title={Lentivirus-mediated inhibition of AQP4 accelerates motor function recovery associated with NGF in spinal cord contusion rats.},
  author={Jianmin Chen and Xi Rui Zeng and Shengnan Li and Zhanqiong Zhong and Xi Hu and Hongyu Xiang and Ying Rao and Lixin Zhang and Xiuya Zhou and Qingjie Xia and Ting-Hua Wang and Xiao Zhang},
  journal={Brain research},
  year={2017},
  volume={1669},
  pages={106-113}
}
Aquaporin-4 (AQP4) is a water channel protein in spinal cord and plays a critical role in the pathophysiological process of spinal cord injury (SCI). However, little is known about the molecular mechanism of AQP4 involved in SCI. The present study was performed to investigate the possible molecules regulated by AQP4 after SCI by use of lentivirus-mediated RNA interference (RNAi). First, the motor function was evaluated by Basso, Beattie, Bresnahan (BBB) scale and the expression of AQP4 was… CONTINUE READING