Lentivirus-mediated gene silencing of KLF8 reduced the proliferation and invasion of gastric cancer cells

@article{Chen2012LentivirusmediatedGS,
  title={Lentivirus-mediated gene silencing of KLF8 reduced the proliferation and invasion of gastric cancer cells},
  author={Gang Chen and Wenjun Yang and Weidong Jin and Yi Wang and Chonglin Tao and Zheng-ping Yu},
  journal={Molecular Biology Reports},
  year={2012},
  volume={39},
  pages={9809-9815}
}
Kruppel-like factor 8 (KLF8) is a transcription factor which has been identified to play a critical role in oncogenic transformation, epithelial-mesenchymal transition and invasion. Higher expression level of KLF8 has been observed in ovarian, renal and breast cancer cells. This study focused on investigating the knockdown effects of KLF8 through lentivirus mediated targeted disruption of KLF8 in gastric cancer cell lines. The expression level of KLF8 is much higher in gastric cancer cells than… CONTINUE READING
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