Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease.

@article{Ridet2006LentivirusmediatedEO,
  title={Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease.},
  author={J L Ridet and Jean-Charles Bensadoun and Nicole D{\'e}glon and P. Aebischer and Anne D. Zurn},
  journal={Neurobiology of disease},
  year={2006},
  volume={21 1},
  pages={29-34}
}
Reactive oxygen species are considered to contribute to the pathogenesis of Parkinson's disease (PD). In order to study viral vector-mediated overexpression of the antioxidant enzyme glutathione peroxidase (GPX) as a potential neuroprotective approach in both an in vitro and in vivo model of PD, we have developed a lentiviral vector carrying the human GPX1 gene. Neuroblastoma cells infected with this vector showed a 2-fold increase in GPX activity compared to cells infected with a control… CONTINUE READING