Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice.

@article{Omata2011LentivirallyMG,
  title={Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice.},
  author={Naoto Omata and Chi-Tso Chiu and P R Moya and Yan Leng and Zhifei Wang and Joshua G. Hunsberger and Peter Leeds and Dr. Chuang},
  journal={The international journal of neuropsychopharmacology},
  year={2011},
  volume={14 5},
  pages={
          711-7
        }
}
Inhibition of glycogen synthase kinase-3 (GSK-3) by pharmacological tools can produce antidepressant-like effects in rodents. However, the GSK-3 isoform(s) and brain region(s) involved in regulating these behavioural effects remain elusive. We studied the effects of bilateral intra-hippocampal injections of lentivirus-expressing short-hairpin (sh)RNA targeting GSK-3β on behavioural performance in mice subjected to chronic stress. Pre-injection of lentivirus-expressing GSK-3β shRNA into the… CONTINUE READING

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