Lentiviral vectors carrying enhancer elements of Hb9 promoter drive selective transgene expression in mouse spinal cord motor neurons.

@article{Peviani2012LentiviralVC,
  title={Lentiviral vectors carrying enhancer elements of Hb9 promoter drive selective transgene expression in mouse spinal cord motor neurons.},
  author={M Peviani and Mami Kurosaki and Mineko Terao and Dario Lidonnici and Francesco Gensano and Elisa Battaglia and Massimo Tortarolo and Roberto Piva and Caterina Bendotti},
  journal={Journal of neuroscience methods},
  year={2012},
  volume={205 1},
  pages={139-47}
}
Recombinant lentiviral vectors (rLVs) have emerged as versatile tools for gene delivery applications due to a number of favorable features, such as the possibility to maintain long-term transgene expression, the flexibility in the design of the expression cassettes and recent improvements in their biosafety profile. Since rLVs are able to infect multiple cell types including post-mitotic cells such as neurons and skeletal muscle cells, several studies have been exploring their application for… CONTINUE READING
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