Lentiviral vector-mediated siRNA knockdown of SR-PSOX inhibits foam cell formation in vitro

@article{Zhang2008LentiviralVS,
  title={Lentiviral vector-mediated siRNA knockdown of SR-PSOX inhibits foam cell formation in vitro},
  author={Li Zhang and Hou-jia Liu and Tiejun Li and Yang Yang and Xian-ling Guo and Meng-chao Wu and Yao-cheng Rui and Lixin Wei},
  journal={Acta Pharmacologica Sinica},
  year={2008},
  volume={29},
  pages={847-852}
}
AbstractAim:To investigate the expression of scavenger receptor that binds phosphatidylserine and oxidized lipoprotein (SR-PSOX)/CXC chemokine ligand 16 (CXCL16) in the human monocyte-derived cell line THP-1, and the effect of lentiviral vectors for the stable delivery of SR-PSOX/CXCL16 short hairpin RNA on foam cell formation.Methods:A lentiviral expression vector containing enhanced green fluorescence protein (GFP) and SR-PSOX small interfering RNA (siRNA) (Lenti-SR-PSOXsi), or the control… CONTINUE READING