Lentiviral vector integration sites in human NOD/SCID repopulating cells.

  title={Lentiviral vector integration sites in human NOD/SCID repopulating cells.},
  author={Stephanie Laufs and Guillermo Guenechea and Africa Gonz{\'a}lez-Murillo and K Zsuzsanna Nagy and M Luz Lozano and Coral del Val and Sunitha Jonnakuty and Agnes Hotz-Wagenblatt and W Jens Zeller and Juan Antonio Bueren and Stefan Fruehauf},
  journal={The journal of gene medicine},
  volume={8 10},
BACKGROUND Recent observations of insertional mutagenesis in preclinical and clinical settings emphasize the relevance of investigating comprehensively the spectrum of integration sites targeted by specific vectors. METHODS We followed the engraftment of lentivirally transduced human cord blood (CB) progenitor cells after transplantation into NOD/SCID mice using a self-inactivating HIV-1-derived vector expressing the enhanced green fluorescent protein (EGFP). RESULTS The mean of… CONTINUE READING


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