Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts.

@article{Moiani2012LentiviralVI,
  title={Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts.},
  author={Arianna Moiani and Ylenia Paleari and Daniela C. Sartori and Riccardo Mezzadra and Annarita Miccio and Claudia Cattoglio and Fabienne Cocchiarella and Maria Rosa Lidonnici and Giuliana Ferrari and Fulvio Mavilio},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 5},
  pages={1653-66}
}
Retroviral vectors integrate in genes and regulatory elements and may cause transcriptional deregulation of gene expression in target cells. Integration into transcribed genes also has the potential to deregulate gene expression at the posttranscriptional level by interfering with splicing and polyadenylation of primary transcripts. To examine the impact of retroviral vector integration on transcript splicing, we transduced primary human cells or cultured cells with HIV-derived vectors carrying… CONTINUE READING
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