Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts.


Retroviral vectors integrate in genes and regulatory elements and may cause transcriptional deregulation of gene expression in target cells. Integration into transcribed genes also has the potential to deregulate gene expression at the posttranscriptional level by interfering with splicing and polyadenylation of primary transcripts. To examine the impact of… (More)
DOI: 10.1172/JCI61852


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